tag:blogger.com,1999:blog-47116849410132836142023-11-15T14:54:40.110+00:00Pills, potions and poisonsComparing formulariesADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.comBlogger35125tag:blogger.com,1999:blog-4711684941013283614.post-91126446038283139652016-06-24T22:00:00.001+01:002016-06-24T22:00:29.905+01:00BrexitThe decision by the UK electorate to leave the European Union will have implications for my project. Even before the vote, I was already assessing the scope for extending the project, and the original comparison between UK and Dutch formularies may well have to be altered if not abandoned. ADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-85803552357418669212016-03-27T21:42:00.001+01:002016-03-27T21:42:47.834+01:00AmitryptilineThis tricyclic antidepressant has quite varying indications when comparing the Dutch and British formularies, and will be one of the focal points in the area of antidepressants in particular, and psychotropics in general. ADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-88814864042847719792016-03-19T16:41:00.005+00:002016-03-19T16:41:40.468+00:00Anti-depressantsMy comparison will continue in the next few days with anti-depressants. This is a fairly large category, which will probably take me about a week to get through. Again, the comparison is not (at this stage) comparing the clinical efficacy of any compound to another, but a formulary comparison. ADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-19182474399344330242016-03-07T21:27:00.000+00:002016-03-07T21:27:13.704+00:00Not marketingI have come across several instances (lurasidone being a case in point) where a manufacturer has registered one or more strengths of their entity, without applying for the strength to be marketed. An enquiry with Takeda, which markets Latuda (lurasidone), as to why 18.5 mg is not available in NL remains open.ADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-25660500252181804422016-02-29T15:19:00.004+00:002016-02-29T15:19:56.867+00:00MeprobamateMeprobamate (marketed as Mogadon) was withdrawn from markets in the EU on recommendation from the EMA in 2012. Yet, the drug remains available in the UK, albeit with the comment that it is not recommended. ADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-63893086153476782532016-02-26T21:48:00.002+00:002016-02-26T21:48:16.382+00:00Anti-psychotics - 3Dutch regulator complains that the half-dose preparation for one anti-psychotic, needed for use in the elderly, is not on the market. It is. In the UK. See the point of my project now? ADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-77949604829578384512016-02-24T18:19:00.001+00:002016-02-24T18:19:40.212+00:00Anti-psychotics - 2Interesting to note that the use of <b>droperidol</b> has been restricted to nausea and vomiting only, and only in the Netherlands is it still being used as an antipsychotic. But even there, it's only through the parenteral route.<br />
<br />
<b>Flupentixol</b> is primarily an anti-psychotic, but its license in the UK also includes depression.<br />
<br />
<b>Fluspirilene </b>is only marked in NL, as a depot preparation for psychosis and mania.<br />
<br />
<br />ADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-47273448957783078382016-02-21T19:57:00.001+00:002016-02-21T19:57:27.837+00:00Antipsychotics - clozapineIt is beginning to strike me that the market for psycho-active prescription medicines is broader in NL than in UK. Having covered clozapine this weekend in this comparison, I am surprised by the difference in monitoring requirements. Clozapine (Clozaril in UK and Leponex in NL) can cause serious abnormalities in blood cell counts (agranulocytosis), which is known to be fatal in certain cases. Clozapine is an important substance, as it can be used when other anti-psychotics fail or are not tolerated. One of the main side-effects of many anti-psychotics are extra-piramidal effects (Parkinson-like symptoms, such as tremors). Clozapine does not have this side-effect, but the risk of fatal agranulocytosis makes it impossible for this compound to be first choice. ADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-60151652132074078292016-02-17T17:19:00.001+00:002016-02-17T17:19:09.240+00:00Benzodiazepines compared<b>Diazepam</b><br />
Dosing schedules<br />
<b> </b><br />
<b>Oxazepam</b><br />
UK has no 5 mg or 25 mg tablets<br />
<b> </b><br />
<b>Alprazolam</b><br />
UK: no slow-release tablets<br />
<b> </b><br />
<b>Prazepam, Bromazepam, Clorazepate, Valerian, Brotizolam</b><br />
Not marketed in UK<br />
<b> </b><br />
<b>Clomethiazole, Zaleplon</b><br />
Not marketed in NL<b> </b><br />
<br />
<b>Temazepam</b><br />
Capsules not marketed in UK<br />
<b> </b><br />
<b>Lormetazepam</b><br />
UK: no 2 mg tablets<br />
NL: no 0.5 mg tablets<br />
<br />
<b>Flunitrazepam</b><br />
UK: only available on private prescription<br />
NL: subject to CD-type restrictionADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-82256441706788400832016-02-12T15:32:00.001+00:002016-02-12T15:32:25.762+00:00BenzodiazepinesHaving completed the comparisons between the Netherlands and the United Kingdom of indications and dosing of benzodiazepines, a number of differences have surfaced. Most are relatively minor. However, there appear to be a larger number of BZD on the market in Holland than in the UK.<br />
<br />
ADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-36681709011240323812016-02-12T14:26:00.000+00:002016-02-12T16:13:44.684+00:00DiazepamATC: N05BA01<br />
DDD: 10 mg<br />
ICD-10: F10, F41, G40, G47, O14, O15<br />
<br />
Tmax: 30-90 minutes<br />
Half-life: 20-48 hours, metabolite N-desmethyldiazepam 42-100 h<br />
Contra-indications: myasthenia gravis, respiratory and hepatic failure, sleep apnea<br />
Not to be used alone in depression or in psychotic illness<br />
<br />
NL: Tablets 2, 5 and 10 mg<br />
Rectal tubes: 2 mg/ml and 4 mg/ml (both 2.5 ml)<br />
Injection: 5 mg/ml, 2 ml amp<br />
<br />
UK: CD4-1<br />
Tablets: 2 and 5 and 10 mg<br />
Oral solution: 2 mg / 5 ml and 5mg/5ml<br />
Injection: 5 mg/ml, 2 ml amp<br />
Rectal tubes: 2 mg /ml (1.25 and 2.5 ml) and 4 mg/ml (2.5 ml)<br />
<br />
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<tr style="mso-yfti-firstrow: yes; mso-yfti-irow: 0;"> <td style="border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> <td style="border-left: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<b style="mso-bidi-font-weight: normal;"><span style="font-size: 18.0pt;">Diazepam</span></b></div>
</td> <td style="border-left: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> </tr>
<tr style="mso-yfti-irow: 1;"> <td style="border-bottom: double windowtext 1.5pt; border-left: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<b style="mso-bidi-font-weight: normal;">Indication </b></div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<b style="mso-bidi-font-weight: normal;">Netherlands</b></div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<b style="mso-bidi-font-weight: normal;">UK</b></div>
</td> </tr>
<tr style="mso-yfti-irow: 2;"> <td style="border-top: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Anxiety</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Oral </div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
2.5 mg 2-3 dd, up to 30 mg</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Oral </div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
2 mg 3dd, up to max daily dose 15-30 mg, elderly half dose</div>
</td> </tr>
<tr style="mso-yfti-irow: 3;"> <td style="border-top: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IM/IV </div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
0.1-0.2 mg/kg, 8 hourly</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IM : </div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
10 mg over 2 mins, repeated (if necessary) after at least 4h</div>
</td> </tr>
<tr style="mso-yfti-irow: 4;"> <td style="border-bottom: double windowtext 1.5pt; border-left: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
PR</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
5-10 mg 2-3dd, 60 mg max</div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> </tr>
<tr style="mso-yfti-irow: 5;"> <td style="border-bottom: double windowtext 1.5pt; border-left: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; border-top: none; mso-border-bottom-alt: double 1.5pt; mso-border-color-alt: windowtext; mso-border-left-alt: solid .5pt; mso-border-right-alt: solid .5pt; mso-border-top-alt: double 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Insomnia</div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-bottom-alt: double 1.5pt; mso-border-color-alt: windowtext; mso-border-left-alt: solid .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid .5pt; mso-border-top-alt: double 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Oral</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
2.5 – 20 mg</div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-bottom-alt: double 1.5pt; mso-border-color-alt: windowtext; mso-border-left-alt: solid .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid .5pt; mso-border-top-alt: double 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Oral</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
5 – 15 mg</div>
</td> </tr>
<tr style="mso-yfti-irow: 6;"> <td style="border-top: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Status epilepticus</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
PR</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Adult 10-20 mg</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Child over 3: 10mg</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Child 1-3: 5 mg</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Child <1: 0.5 mg/kg</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
PR</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Adult & child over 12: 10-20 mg, elderly 10 mg<br />
Neonate: 1.25-2.5 mg<br />
Child 1-12 months: 5 mg<br />
Child 1-2 years: 5 mg<br />
Child 2-12 years: 5-10 mg </div>
</td> </tr>
<tr style="mso-yfti-irow: 7;"> <td style="border-bottom: double windowtext 1.5pt; border-left: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IV/IM</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Adult 0.15-0.25 mg/kg</div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IV/IM</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
10 mg over 2 mins, repeat once after 10 mins<br />
Child under 12: 0.3-0.4 mg/kg, max 10 mg</div>
</td> </tr>
<tr style="mso-yfti-irow: 8;"> <td style="border-top: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Muscular spasms</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Oral</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
15 mg / day 2-4 doses, up to 60mg</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> </tr>
<tr style="mso-yfti-irow: 9;"> <td style="border-top: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IV/IM</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
2-20 mg</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IV</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
5-10 mg</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Child 1-12 months: 0.1 mg/kg</div>
</td> </tr>
<tr style="mso-yfti-irow: 10;"> <td style="border-bottom: double windowtext 1.5pt; border-left: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
PR</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
10-20 mg 2-3 dd</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Child: 0.04-0.2 mg/ kg</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Max 0.6 mg/kg/8 h</div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
PR<br />
0.5 mg/kg, elderly half dose</div>
</td> </tr>
<tr style="mso-yfti-irow: 11;"> <td style="border-bottom: double windowtext 1.5pt; border-left: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; border-top: none; mso-border-bottom-alt: double 1.5pt; mso-border-color-alt: windowtext; mso-border-left-alt: solid .5pt; mso-border-right-alt: solid .5pt; mso-border-top-alt: double 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Upper motoric nerves</div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-bottom-alt: double 1.5pt; mso-border-color-alt: windowtext; mso-border-left-alt: solid .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid .5pt; mso-border-top-alt: double 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
15 mg / day 2-4 doses, max 60 mg</div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-bottom-alt: double 1.5pt; mso-border-color-alt: windowtext; mso-border-left-alt: solid .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid .5pt; mso-border-top-alt: double 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> </tr>
<tr style="mso-yfti-irow: 12;"> <td style="border-top: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Febrile convulsions</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
PR</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
0.25 – 0.5 mg/kg</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Adult: 20mg, repeat after 10 mins, half dose in elderly</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Child: 10-15 kg: 5 mg</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Child: > 15 kg: 10 mg</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
PR</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Adult & child over 12: 10-20 mg, elderly 10 mg<br />
Neonate: 1.25-2.5 mg<br />
Child 1-12 months: 5 mg<br />
Child 1-2 years: 5 mg<br />
Child 2-12 years: 5-10 mg</div>
</td> </tr>
<tr style="mso-yfti-irow: 13;"> <td style="border-bottom: double windowtext 1.5pt; border-left: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IV</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
0.2-0.5 mg/kg</div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IV/IM</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
10 mg over 2 mins, repeat once after 10 mins<br />
Child under 12: 0.3-0.4 mg/kg, max 10 mg</div>
</td> </tr>
<tr style="mso-yfti-irow: 14;"> <td style="border-top: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Tetanus</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
PR</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
0.25 – 0.5 mg/kg</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Adult: 20mg, repeat after 10 mins, half dose in elderly</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Child: 10-15 kg: 5 mg</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Child: > 15 kg: 10 mg</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> </tr>
<tr style="mso-yfti-irow: 15;"> <td style="border-bottom: double windowtext 1.5pt; border-left: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IV</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
0.1 – 0.3 mg/kg every 1-4 h, max 4 mg/kg/day</div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> </tr>
<tr style="mso-yfti-irow: 16;"> <td style="border-top: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Alcohol withdrawal</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
Oral</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
5-20 mg, repeat once after 2-4 h, 10 mg 3-4 dd, reduce 5 mg 3-4 dd<br />
Hospital: 10 mg hourly till asymptomatic, up to 80 mg</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> </tr>
<tr style="mso-yfti-irow: 17;"> <td style="border-top: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IV</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
0.1-0.2 mg/kg, every 8h</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IM : 10 mg over 2 mins, repeated (if necessary) after at least 4h</div>
</td> </tr>
<tr style="mso-yfti-irow: 18;"> <td style="border-bottom: double windowtext 1.5pt; border-left: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
PR</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
20 mg 3dd for 24 hours, then 10 mg 3 dd</div>
</td> <td style="border-bottom: double windowtext 1.5pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-bottom-alt: double windowtext 1.5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> </tr>
<tr style="mso-yfti-irow: 19; mso-yfti-lastrow: yes;"> <td style="border-top: none; border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.2pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
(Pre) Eclampsia, post partum</div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
IV</div>
<div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
10-20 mg </div>
</td> <td style="border-bottom: solid windowtext 1.0pt; border-left: none; border-right: solid windowtext 1.0pt; border-top: none; mso-border-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-top-alt: double windowtext 1.5pt; mso-border-top-alt: double windowtext 1.5pt; padding: 0cm 5.4pt 0cm 5.4pt; width: 164.25pt;" valign="top" width="219"><div class="MsoNormal" style="line-height: normal; margin-bottom: .0001pt; margin-bottom: 0cm;">
<br /></div>
</td> </tr>
</tbody></table>
ADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-37214802154438571242016-02-12T14:20:00.001+00:002016-02-12T14:20:39.933+00:00OxazepamATC: N05BA04<br />
DDD: 50 mg oral<br />
ICD-10: F41, G47, F10<br />
<br />Tmax: 2-3 h<br />
Half life: 4-15 h<br />
Contra-indications: myasthenia gravis, liver and respiratory failure and sleep apnea<br />
<br />
Dose<br />
Anxiety: 10 mg 3-4dd in mild cases, 50 mg in severe cases, up to 100-300 mg daily<br />
UK: 15-30 mg, but 10-20 mg in elderly or infirm<br />
<br />
Anxiety with depression: 10-20 mg 3-4dd, also for alcohol withdrawal (not more than 1 week)<br />
Child under 6: 10-30 mg per day in divided doses<br />
Child 6-12 years: 10-40 mg<br />
Insomnia: 15-30 mg<br />
<br />
NL: 5, 10, 25, 50 mg tablets (Seresta)<br />UK: CD4-1. 10 and 15 mg tablets (non-propr)ADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-46535695996198839202016-02-10T12:27:00.004+00:002016-02-12T14:14:47.346+00:00AlprazolamATC: N05BA12<br />
DDD: 1 mg oral<br />
ICD-10: F41<br />
<br />
Tmax (tablets): 1-2 h, Retard tablets 5 - 11 h<br />
Half-life: 12-15 h, elderly 16 h<br />
Contra-indications: Myasthenia gravis, respiratory and hepatic failure, sleep apnea<br />
<br />
Dose: Start on 0.25 - 0.5 mg 3 dd, then 0.5 - 3 mg daily in divided doses<br />
Retard tablet: Start 1 mg 1-2 dd, then 0.5 - 3 mg daily in divided doses<br />
<br />
NL: 0.25 and 0.5 mg tablets, Retard tablets 0.5, 1 and 2 mg (Xanax)<br />
UK: CD4-1, not NHS<br />
0.25 and 0.5 mg tablets, XanaxADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-58898064184863241792016-02-10T12:24:00.002+00:002016-02-10T12:24:31.715+00:00PrazepamATC: N05BA11<br />
DDD: 30 mg<br />
ICD-10: F41<br />
<br />
First pass effect to N-desmethyldiazepam, tmax 6 h<br />
Half -life: 42-100 hours, metabolite<br />
Contra-indications: myasthenia gravis, respiratory and hepatic failure<br />
<br />
Dose: 10 - 60 mg, usually 30 mg, for no longer than 8 to 12 weeks, decrease out slowly<br />
Elderly, hepatic, renal and respiratory failure: start at 10-15 mg<br />
<br />
NL: 10 mg tablets (Reapam)<br />
UK: Not marketedADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-35365758051534438672016-02-10T12:22:00.002+00:002016-02-10T12:22:35.009+00:00BromazepamATC: N05BA08<br />
DDD: 10 mg oral<br />
ICD-10: F41<br />
<br />
Tmax: 1-2 h<br />
Half life: 15 - 22 h<br />
CI: myasthenia gravis, respiratory and hepatic failure, sleep apnea<br />
<br />
Dose: 1.5 - 3 mg, 3 dd, in severe anxiety 6 - 12 mg 2-3 dd; for not longer than 2 weeks<br />
<br />
UK: Not marketed<br />
NL: 1.5, 3 and 6 mg tabletsADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-88574724577371327612016-02-09T11:45:00.002+00:002016-02-12T16:18:51.791+00:00LorazepamATC: N05BA06<br />
DDD: 2.5 mg oral, parenteral and sub-lingual<br />
ICD-10: F41, G41, G47<br />
<br />
Tmax 2 h, half-life 12 to 16 hours<br />
Contra-indications: Myasthenia gravis, respiratory or hepatic insuffiency, sleep apnea<br />
<br />
Dose:<br />
NL: Anxiety: 0.5 mg 2-3 dd, increased to 1 mg 2-3 dd<br />
Severe anxiety: 1.25 - 2.5 mg 2-3 dd<br />
IV/IM: 2-4 mg, repeat after 2h if necessary <br />
Sleep: 1-2 mg at night<br />
<br />
UK: 1-4 mg daily in divided doses; elderly half doses<br />
Insomnia: 1-2 mg at bedtime<br />
IM/IV: 25-30 mcg/kg (1.5-2.5mg) every 6 hours<br />
<br />
NL: 0.5, 1 and 2.5 mg tablets (Temesta)<br />
Injection: 4 mg / ml<br />
<br />
UK: CD4-1<br />
1 and 2.5 mg tablets<br />
Injection: 4 mg / ml (Ativan)<br />
Also for status epilepticusADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-67384091221315550392016-02-09T11:42:00.002+00:002016-02-09T11:42:43.358+00:00ClorazepateATC: N05BA05<br />
DDD: 20 mg oral<br />
ICD-10: F41, F10<br />
<br />
Metabolised to active metabolite N-desmethyldiazepam<br />
Tmax 45 minutes, half-life 2-3 hours<br />
Metabolite half-life: 42 to 96 hours<br />
Contra-indications: Myasthenia gravis, respiratory and hepatic insuffiency, sleep apnea<br />
<br />
Dose<br />
Anxiety: 5 mg 3 dd, up to 50 mg 3dd, up to 300 mg in a day<br />
Alcohol withdrawal: 200 to 300 mg in divided doses, IM 20-40 mg every 2 h<br />
<br />
UK: Not marketed<br />
NL: Tranxene<br />
5 and 10 mg caps<br />
Film-coated tabs 20 mg MB (can be quartered), and 50 mgADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-29980402943754901632016-02-08T12:46:00.000+00:002016-02-12T15:17:22.432+00:00ClobazamATC: N05BA09<br />
DDD: 20 mg oral<br />
ICD-10: F41, G40<br />
<br />
tmax: 0.5 - 4 h<br />
Half life: 18-30 h, metabolites 50 h<br />
Renal and liver insufficiency, myasthenia gravis<br />
<br />
Dose:<br />
Anxiety: 10 mg 2-3dd, or 20 mg at night, up to 60 mg, not longer than 8 - 12 weeks<br />
<br />
Epilepsy:<br />
NL: start 5-15 mg, up to 80 mg<br />
child 5 mg / day, 0.3-1 mg / kg / day<br />
UK: 20-30 mg daily, up to 60 mg<br />
child 5 mg / day, 0.3-1 mg / kg / day<br />
<br />
NL: 5, 10, 20 mg tabs (Frisium 10, 20 mg)<br />
<br />
UK: CD4-1<br />
10 mg tabs (Frisium, NHS only for epilepsy)<br />
suspension 5 mg / 5mlADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-53106146664547357962016-02-08T12:43:00.000+00:002016-02-12T15:13:39.536+00:00ChlordiazepoxideATC: N05BA02<br />
DDD: 30 mg oral, 50 mg parenteral<br />
ICD-10: F41, F10<br />
<br />
Half life: 9 h, metabolites 40-50 h<br />
Liver / renal impairment<br />
<br />
Dose:<br />
NL: Anxiety: 5 - 10 mg, 3-4 dd, up to 20 - 25 mg<br />
UK: 10 mg 3dd, up to 60-100 mg in divided doses; elderly half dose <br />
Alcohol detox (UK only) 10-50 mg 4 dd, reduce over 7-10 days<br />
<br />
NL: 5, 10 and 25 mg tablets<br />
UK: CD4-1<br />
5 mg tablets and 5 mg caps. Librium non-NHSADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-86013596202060788132016-02-08T12:41:00.001+00:002016-02-08T12:41:25.171+00:00ValerianATC: N05CM09<br />
DDD: -<br />
ICD-10: G47<br />
<br />
UK: not marketed<br />
NL: Nerviplant 500 mg tabs<br />
Tendo tincture<br />
Valdispert 45 mg coated tabs<br />
<br />
Dose:<br />Valdispert:<br />
Insomnia, 1 at night<br />
Anxiety: 1-3 tabs 3 x daily<br />
<br />
Nerviplant:<br />
Anxiety: 1-3 tabs up to 4 x daily<br />
<br />
Not held to have great efficacyADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-76617654461919132042016-02-07T16:27:00.003+00:002016-02-07T16:27:43.684+00:00ClomethiazoleATC: N05CM02<br />
DDD: 1.5 g oral / parenteral<br />
ICD-10: G47, F10.3<br />
<br />
Dose: 1 to 2 capsules, insomnia in the elderly<br />
Contra-indications: hepatic, renal and respiratory insufficiency<br />
<br />
Alcohol withdrawal treatment: not longer than 9 days<br />
<br />
NL: Not marketed<br />
UK: 192 mg capsules<br />
157.5 mg / 5ml oral solutionADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-34241370297660048842016-02-07T16:25:00.003+00:002016-02-12T15:11:25.372+00:00ZaleplonATC: N05CF03<br />
DDD: 10 mg oral<br />
ICD-10: G47<br />
<br />
Half-life: 1 hour<br />
Dose: 10 mg (elderly 5 mg) at night (up to 2 weeks)<br />
Contra-indications: hepatic, renal and respiratory insufficiency; myasthenia gravis and sleep apnea<br />
<br />
NL: not marketed<br />
UK: CD4-1<br />
Sonata, 5 and 10 mg capsulesADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-47309609729873976892016-02-07T16:24:00.001+00:002016-02-12T15:09:31.486+00:00ZopicloneATC: N05CF01<br />
DDD: 7.5 mg oral<br />
ICD-10: G47<br />
<br />
Max level after 45 to 120 minutes<br />
Half life: 5 hours, elderly 7 hours, in liver cirrhosis 10 hours<br />
Dose: 7.5 mg at night, for 2 weeks, max 4 weeks<br />
Start on 3.75 mg in the elderly and with liver and renal insuffiency<br />
Contra-indications: myasthenia gravis, liver and renal insufficiency, sleep apnea<br />
Interactions around CYP3A4 metabolism<br />
<br />
UK: CD 4-1. Zimovane 3.75 and 7.5 mg<br />
NL: Imovane 3.75 and 7.5 mgADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-53286332468970714682016-02-07T16:22:00.001+00:002016-02-12T15:07:11.938+00:00ZolpidemATC: N05CF02<br />
DDD: 10 mg oral<br />
ICD-10: G47<br />
<br />
Dose: 10 mg at night (up to 4 weeks), elderly 5 mg <br />
Max level after ½ to 3 hours<br />
Contra-indications: myasthenia gravis, sleep apnea, respiratory, hepatic and renal insufficiency<br />
Interactions related to CYP3A4 metabolism<br />
<br />
NL: Stilnoct and non-proprietary, 5 and 10 mg tablets<br />
UK: CD 4-1; Stilnoct and non-proprietary 5 and 10 mg tabletsADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0tag:blogger.com,1999:blog-4711684941013283614.post-26617453674379407122016-02-05T22:12:00.001+00:002016-02-12T15:05:47.879+00:00TemazepamATC: N05CD07<br />
DDD: 20 mg oral<br />
ICD-10: G47<br />
<br />
Dose: 10 - 20 mg, exceptionally 30 - 40 mg<br />
Conscious sedation (dental procedures): 15 - 30 mg<br />
Contra-indications: hepatic and renal failure, myasthenia gravis<br />
Max level after 50 minutes <br />
Half life: 7 - 11 hours<br />
<br />
NL: Capsules 10 and 20 mg, Normison;<br />
Tablets 10 and 20mg<br />
Oral solution: 30 mg/ml<br />
<br />
UK (CD 3): Tablets 10 mg and 20 mg<br />
Oral solution: 10 mg / 5mlADBhttp://www.blogger.com/profile/17737746983905368038noreply@blogger.com0