Diazepam

ATC: N05BA01
DDD: 10 mg
ICD-10: F10, F41, G40, G47, O14, O15

Tmax: 30-90 minutes
Half-life: 20-48 hours, metabolite N-desmethyldiazepam 42-100 h
Contra-indications: myasthenia gravis, respiratory and hepatic failure, sleep apnea
Not to be used alone in depression or in psychotic illness

NL: Tablets 2, 5 and 10 mg
Rectal tubes: 2 mg/ml and 4 mg/ml (both 2.5 ml)
Injection: 5 mg/ml, 2 ml amp

UK: CD4-1
Tablets: 2 and 5 and 10 mg
Oral solution: 2 mg / 5 ml and 5mg/5ml
Injection: 5 mg/ml, 2 ml amp
Rectal tubes: 2 mg /ml (1.25 and 2.5 ml) and 4 mg/ml (2.5 ml)

	Diazepam
Indication	Netherlands	UK
Anxiety	Oral 2.5 mg 2-3 dd, up to 30 mg	Oral 2 mg 3dd, up to max daily dose 15-30 mg, elderly half dose
	IM/IV 0.1-0.2 mg/kg, 8 hourly	IM : 10 mg over 2 mins, repeated (if necessary) after at least 4h
	PR 5-10 mg 2-3dd, 60 mg max
Insomnia	Oral 2.5 – 20 mg	Oral 5 – 15 mg
Status epilepticus	PR Adult 10-20 mg Child over 3: 10mg Child 1-3: 5 mg Child <1: 0.5 mg/kg	PR Adult & child over 12: 10-20 mg, elderly 10 mg Neonate: 1.25-2.5 mg Child 1-12 months: 5 mg Child 1-2 years: 5 mg Child 2-12 years: 5-10 mg
	IV/IM Adult 0.15-0.25 mg/kg	IV/IM 10 mg over 2 mins, repeat once after 10 mins Child under 12: 0.3-0.4 mg/kg, max 10 mg
Muscular spasms	Oral 15 mg / day 2-4 doses, up to 60mg
	IV/IM 2-20 mg	IV 5-10 mg Child 1-12 months: 0.1 mg/kg
	PR 10-20 mg 2-3 dd Child: 0.04-0.2 mg/ kg Max 0.6 mg/kg/8 h	PR 0.5 mg/kg, elderly half dose
Upper motoric nerves	15 mg / day 2-4 doses, max 60 mg
Febrile convulsions	PR 0.25 – 0.5 mg/kg Adult: 20mg, repeat after 10 mins, half dose in elderly Child: 10-15 kg: 5 mg Child: > 15 kg: 10 mg	PR Adult & child over 12: 10-20 mg, elderly 10 mg Neonate: 1.25-2.5 mg Child 1-12 months: 5 mg Child 1-2 years: 5 mg Child 2-12 years: 5-10 mg
	IV 0.2-0.5 mg/kg	IV/IM 10 mg over 2 mins, repeat once after 10 mins Child under 12: 0.3-0.4 mg/kg, max 10 mg
Tetanus	PR 0.25 – 0.5 mg/kg Adult: 20mg, repeat after 10 mins, half dose in elderly Child: 10-15 kg: 5 mg Child: > 15 kg: 10 mg
	IV 0.1 – 0.3 mg/kg every 1-4 h, max 4 mg/kg/day
Alcohol withdrawal	Oral 5-20 mg, repeat once after 2-4 h, 10 mg 3-4 dd, reduce 5 mg 3-4 dd Hospital: 10 mg hourly till asymptomatic, up to 80 mg
	IV 0.1-0.2 mg/kg, every 8h	IM : 10 mg over 2 mins, repeated (if necessary) after at least 4h
	PR 20 mg 3dd for 24 hours, then 10 mg 3 dd
(Pre) Eclampsia, post partum	IV 10-20 mg