Lorazepam

ATC: N05BA06
DDD: 2.5 mg oral, parenteral and sub-lingual
ICD-10: F41, G41, G47

Tmax 2 h, half-life 12 to 16 hours
Contra-indications: Myasthenia gravis, respiratory or hepatic insuffiency, sleep apnea

Dose:
NL: Anxiety: 0.5 mg 2-3 dd, increased to 1 mg 2-3 dd
Severe anxiety: 1.25 - 2.5 mg 2-3 dd
IV/IM: 2-4 mg, repeat after 2h if necessary
Sleep: 1-2 mg at night

UK: 1-4 mg daily in divided doses; elderly half doses
Insomnia: 1-2 mg at bedtime
IM/IV: 25-30 mcg/kg (1.5-2.5mg) every 6 hours

NL: 0.5, 1 and 2.5 mg tablets (Temesta)
Injection: 4 mg / ml

UK: CD4-1
1 and 2.5 mg tablets
Injection: 4 mg / ml (Ativan)
Also for status epilepticus

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